Synthesis and antibacterial activity of novel Schiff bases of thiosemicarbazone derivatives with adamantane moiety

Increased bacterial resistance to antibiotics is a major threat human health, and it particularly important develop novel antibiotic drugs. Here, we designed series of Schiff base thiosemicarbazone derivatives containing an adamantane moiety, carried out the structural characterization compounds in vitro antibacterial activity tests. Compound 7e was as effective commonly used ampicillin against Gram-negative bacterium Escherichia coli, compound 7g had good inhibitory effect Gram-positive Bacillus subtilis. These findings provide data for development better agents.